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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Hypomethylating agent ： ウィキペディア英語版 Hypomethylating agent A hypomethylating agent (or demethylating agent) is a drug that inhibits DNA methylation. Currently available hypomethylating agents block the activity of DNA methyltransferase (DNA methyltransferase inhibitors / DNMT inhibitors). Because DNA methylation affects cellular function through successive generations of cells without changing the underlying DNA sequence, hypomethylating agents are considered a type of epigenetic therapy. Currently two members of the class, azacitidine and decitabine are FDA-approved for use in the United States in myelodysplastic syndrome and are being investigated for use in a number of tumors. ==Clinical use== Two hypomethylating agents are approved for the treatment of myelodysplastic syndrome by the United States FDA〔(【引用サイトリンク】title=Azacitadine - National Cancer Institute )〕〔(【引用サイトリンク】title=Decitabine - National Cancer Institute )〕 * decitabine * azacitidine 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Hypomethylating agent」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.